Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

¹ Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
² Microvascular and Molecular Neuro-Oncology Laboratory, Department of Pathology, Kaplan Cancer Center, New York University Medical Center, New York, NY 10016, USA.

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Jun 1999	1061	1759	898
Jul 1999	117	626	286
Aug 1999	50	260	113
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Nov 1999	46	259	92
Dec 1999	46	186	74
Jan 2000	69	231	120
Feb 2000	59	223	88
Mar 2000	28	266	99
Apr 2000	32	192	92
May 2000	34	172	96
Jun 2000	31	132	74
Jul 2000	14	121	52
Aug 2000	15	116	76
Sep 2000	34	144	61
Oct 2000	52	191	100
Nov 2000	30	146	76
Dec 2000	13	157	82
Jan 2001	27	131	73
Feb 2001	28	120	51
Mar 2001	52	177	82
Apr 2001	79	208	99
May 2001	42	127	56
Jun 2001	38	120	62
Jul 2001	25	112	66
Aug 2001	27	81	47
Sep 2001	20	94	61
Oct 2001	15	102	66
Nov 2001	43	141	81
Dec 2001	19	75	38
Jan 2002	36	137	64
Feb 2002	29	141	41
Mar 2002	40	165	120
Apr 2002	33	128	81
May 2002	37	129	81
Jun 2002	51	133	93
Jul 2002	24	96	65
Aug 2002	40	97	49
Sep 2002	26	100	62
Oct 2002	28	100	90
Nov 2002	22	108	84
Dec 2002	32	81	66
Jan 2003	22	121	92
Feb 2003	33	120	69
Mar 2003	28	107	82
Apr 2003	35	126	85
May 2003	31	101	61
Jun 2003	28	105	104
Jul 2003	69	93	65
Aug 2003	54	103	56
Sep 2003	37	76	69
Oct 2003	48	123	82
Nov 2003	45	102	72
Dec 2003	43	76	56
Jan 2004	39	109	60
Feb 2004	41	85	69
Mar 2004	36	104	54
Apr 2004	53	119	92
May 2004	63	117	72
Jun 2004	71	107	51
Jul 2004	68	77	34
Aug 2004	80	91	54
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Oct 2004	73	119	77
Nov 2004	92	145	65
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Apr 2005	40	86	69
May 2005	35	97	71
Jun 2005	73	92	65
Jul 2005	42	62	43
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Nov 2006	57	45	42
Dec 2006	41	24	27
Jan 2007	21	38	46
Feb 2007	25	35	37
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Apr 2007	38	49	49
May 2007	39	46	35
Jun 2007	24	27	34
Jul 2007	51	33	28
Aug 2007	26	28	34
Sep 2007	18	23	37
Oct 2007	31	53	54
Nov 2007	41	43	52
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Jan 2008	44	54	44
Feb 2008	43	58	59
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Apr 2008	55	38	36
May 2008	128	40	40
Jun 2008	73	31	29
Jul 2008	43	42	37
Aug 2008	45	39	36
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Nov 2008	71	38	36
Dec 2008	45	28	34
Jan 2009	38	32	33
Feb 2009	51	25	37
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Apr 2009	60	40	44
May 2009	50	54	45
Jun 2009	32	47	42
Jul 2009	53	32	35
Aug 2009	26	38	29
Sep 2009	43	34	32
Oct 2009	56	42	54
Nov 2009	46	35	40
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Jan 2010	49	40	37
Feb 2010	49	31	38
Mar 2010	57	37	38
Apr 2010	37	27	29
May 2010	42	21	19
Jun 2010	45	33	31
Jul 2010	52	39	39
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Nov 2010	82	52	40
Dec 2010	64	41	32
Jan 2011	88	59	44
Feb 2011	70	46	29
Mar 2011	87	37	39
Apr 2011	72	39	33
May 2011	63	27	21
Jun 2011	78	24	25
Jul 2011	69	23	27
Aug 2011	42	30	20
Sep 2011	79	32	24
Oct 2011	57	35	34
Nov 2011	63	26	32
Dec 2011	64	17	24
Jan 2012	72	14	22
Feb 2012	87	17	26
Mar 2012	94	13	18
Apr 2012	77	21	15
May 2012	79	6	11
Jun 2012	80	28	23
Jul 2012	64	26	21
Aug 2012	82	37	26
Sep 2012	99	31	38
Oct 2012	102	33	29
Nov 2012	76	34	26
Dec 2012	79	33	22
Jan 2013	100	30	27
Feb 2013	68	23	16
Mar 2013	122	29	30
Apr 2013	125	30	26
May 2013	64	31	30
Jun 2013	56	27	22
Jul 2013	60	30	19
Aug 2013	67	23	19
Sep 2013	83	43	32
Oct 2013	73	50	28
Nov 2013	67	21	19
Dec 2013	77	23	26
Jan 2014	94	21	29
Feb 2014	76	23	21
Mar 2014	94	42	39
Apr 2014	96	26	22
May 2014	117	30	28
Jun 2014	67	17	15
Jul 2014	101	20	15
Aug 2014	46	25	22
Sep 2014	58	16	18
Oct 2014	73	44	34
Nov 2014	86	30	20
Dec 2014	79	21	17
Jan 2015	57	18	19
Feb 2015	70	36	22
Mar 2015	71	39	24
Apr 2015	67	32	19
May 2015	51	32	11
Jun 2015	58	36	23
Jul 2015	52	29	22
Aug 2015	84	31	18
Sep 2015	90	14	6
Oct 2015	78	26	17
Nov 2015	49	21	10
Dec 2015	82	17	14
Jan 2016	94	14	11
Feb 2016	115	9	9
Mar 2016	87	11	26
Apr 2016	99	20	25
May 2016	77	23	25
Jun 2016	118	19	19
Jul 2016	117	8	23
Aug 2016	110	11	25
Sep 2016	85	16	27
Oct 2016	199	9	21
Nov 2016	244	19	26
Dec 2016	133	10	22
Jan 2017	100	11	15
Feb 2017	67	8	9
Mar 2017	84	20	21
Apr 2017	79	16	20
May 2017	118	20	24
Jun 2017	77	17	18
Jul 2017	150	14	19
Aug 2017	120	8	31
Sep 2017	131	13	20
Oct 2017	229	12	25
Nov 2017	222	14	17
Dec 2017	134	13	9
Jan 2018	102	15	8
Feb 2018	102	23	13
Mar 2018	97	20	25
Apr 2018	127	22	19
May 2018	143	15	18
Jun 2018	125	9	19
Jul 2018	95	16	16
Aug 2018	76	17	15
Sep 2018	111	61	15
Oct 2018	130	43	18
Nov 2018	78	47	17
Dec 2018	82	56	7
Jan 2019	182	64	20
Feb 2019	149	44	13
Mar 2019	120	40	26
Apr 2019	117	43	20
May 2019	55	55	20
Jun 2019	43	41	10
Jul 2019	45	72	29
Aug 2019	68	50	23
Sep 2019	41	50	14
Oct 2019	39	78	14
Nov 2019	40	61	18
Dec 2019	41	52	14
Jan 2020	30	67	17
Feb 2020	39	35	8
Mar 2020	41	46	10
Apr 2020	60	50	17
May 2020	39	55	7
Jun 2020	41	36	6
Jul 2020	34	30	10
Aug 2020	39	34	11
Sep 2020	68	80	15
Oct 2020	44	59	15
Nov 2020	72	34	10
Dec 2020	60	50	9
Jan 2021	60	45	23
Feb 2021	58	24	11
Mar 2021	2	0	0

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