Inhibition of the Interferon- Inducible Protein Kinase PKR by HCV E2 Protein

See allHide authors and affiliations

Science  02 Jul 1999:
Vol. 285, Issue 5424, pp. 107-110
DOI: 10.1126/science.285.5424.107

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Most isolates of hepatitis C virus (HCV) infections are resistant to interferon, the only available therapy, but the mechanism underlying this resistance has not been defined. Here it is shown that the HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PKR and the translation initiation factor eIF2α, a target of PKR. E2 inhibited the kinase activity of PKR and blocked its inhibitory effect on protein synthesis and cell growth. This interaction of E2 and PKR may be one mechanism by which HCV circumvents the antiviral effect of interferon.

  • * To whom correspondence should be addressed. E-mail: michlai{at}

View Full Text

Stay Connected to Science