09 July 1999
Vol 285, Issue 5425

About The Cover

Cover image expansion

COVER Immunological synapse formation. An electron micrograph (EM) was merged with a live-cell fluorescence micrograph (FM) to show this key event in T cell activation. The immunological synapse is indicated by the bull's-eye pattern of adhesion molecules (red) and antigen receptors (green) at the interface between a T lymphocyte (~7 µm) (purple) and a dendritic cell (dark green). See page 221 [Images: EM, reprinted by permission of Wiley-Liss, a subsidiary of John Wiley & Sons, Inc. © 1993 Setum et al., Anatomical Record, 235, p. 285; FM, M. L. Dustin]