Detecting Protein Function and Protein-Protein Interactions from Genome Sequences

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Science  30 Jul 1999:
Vol. 285, Issue 5428, pp. 751-753
DOI: 10.1126/science.285.5428.751

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A computational method is proposed for inferring protein interactions from genome sequences on the basis of the observation that some pairs of interacting proteins have homologs in another organism fused into a single protein chain. Searching sequences from many genomes revealed 6809 such putative protein-protein interactions inEscherichia coli and 45,502 in yeast. Many members of these pairs were confirmed as functionally related; computational filtering further enriches for interactions. Some proteins have links to several other proteins; these coupled links appear to represent functional interactions such as complexes or pathways. Experimentally confirmed interacting pairs are documented in a Database of Interacting Proteins.

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