05 November 1999
Vol 286, Issue 5442

About The Cover

Cover image expansion

COVER Combined fluorescence images of focal adhesions (multicolored patches) and microfilaments (red) in a stationary fibroblast expressing green fluorescent protein-integrin (image width, ~50 mm). Color-encoded time-lapse images of the focal adhesions (earliest, orange; latest, purple) show that focal adhesions move while remaining connected to microfilaments. Immotile focal adhesions in migrating cells may reflect the activity of a molecular clutch. See page 1172 [Image: A. Mikhailov and G. G. Gundersen]