03 December 1999
Vol 286, Issue 5446

About The Cover

Cover image expansion

COVER The yellow area (left) shows a red-stained misfolded protein colocalizing with a green-stained molecular chaperone in the endoplasmic reticulum (ER) (image width, ~12 mm). After a shift from 39.5° to 32°C, the protein folds properly, passes quality control, leaves the ER, and enters vesiculotubular clusters (red spots on the right) en route to the cell surface. This special issue looks at quality control mechanisms in the cell, beginning on p. 1881 [Image: Anna Mezzacasa and Ari Helenius]