Structural Assets of a Tumor Suppressor

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Science  10 Dec 1999:
Vol. 286, Issue 5447, pp. 2096-2097
DOI: 10.1126/science.286.5447.2096

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PTEN is one of the most frequently mutated tumor suppressor proteins in human cancer. Many investigators are interested in what this protein does and how disruption of its activity enables cells to circumvent growth control. In a Perspective, Tonks and Myers discuss the recent publication of the crystal structure of PTEN and what the structure tells us about PTEN's ability to remove phosphate groups from proteins and phospholipids and how this relates to its anti-cancer function.