Cross-Species Interactions Between Malaria Parasites in Humans

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Science  04 Feb 2000:
Vol. 287, Issue 5454, pp. 845-848
DOI: 10.1126/science.287.5454.845

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The dynamics of multiple Plasmodium infections in asymptomatic children living under intense malaria transmission pressure provide evidence for a density-dependent regulation that transcends species as well as genotype. This regulation, in combination with species- and genotype-specific immune responses, results in nonindependent, sequential episodes of infection with each species.

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