Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

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Science  03 Mar 2000:
Vol. 287, Issue 5458, pp. 1606-1609
DOI: 10.1126/science.287.5458.1606

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The Wnt cell-cell signaling pathway plays a critical and evolutionarily conserved role in directing cell fates during embryogenesis. In addition, inappropriate activation of the Wnt signal transduction pathway plays a role in a variety of human cancers. Many recent studies of Wnt signaling have provided mechanistic insight into these dual roles. Here we focus on two areas of rapid advance: (i) the machinery that regulates the stability of the key signal transducer, β-catenin, and (ii) the effect of Wnt signaling on cellular targets outside the nucleus, the actin and microtubule cytoskeletons.

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