Research Article

A Drosophila Mechanosensory Transduction Channel

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Science  24 Mar 2000:
Vol. 287, Issue 5461, pp. 2229-2234
DOI: 10.1126/science.287.5461.2229

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Mechanosensory transduction underlies a wide range of senses, including proprioception, touch, balance, and hearing. The pivotal element of these senses is a mechanically gated ion channel that transduces sound, pressure, or movement into changes in excitability of specialized sensory cells. Despite the prevalence of mechanosensory systems, little is known about the molecular nature of the transduction channels. To identify such a channel, we analyzedDrosophila melanogaster mechanoreceptive mutants for defects in mechanosensory physiology. Loss-of-function mutations in theno mechanoreceptor potential C (nompC) gene virtually abolished mechanosensory signaling. nompC encodes a new ion channel that is essential for mechanosensory transduction. As expected for a transduction channel, D. melanogaster NOMPC and a Caenorhabditis elegans homolog were selectively expressed in mechanosensory organs.

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