14 April 2000
Vol 288, Issue 5464

About The Cover

Cover image expansion

COVER This genetically modified mouse lacks the receptor for capsaicin (the pungent ingredient in chili peppers) and no longer avoids the spicy Habanero pepper. These mice also exhibit a reduction in their ability to detect protons or heat under normal or pathophysiological conditions, illustrating a requirement for the capsaicin receptor in detecting diverse modalities of pain-producing stimuli. See page 306 [Photo: G. Hollopeter and A. DePace]