Control of Homeostasis of CD8+ Memory T Cells by Opposing Cytokines

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Science  28 Apr 2000:
Vol. 288, Issue 5466, pp. 675-678
DOI: 10.1126/science.288.5466.675

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Memory T cells maintain their numbers for long periods after antigen exposure. Here we show that CD8+ T cells of memory phenotype divide slowly in animals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2). Therefore, the numbers of CD8+ memory T cells in animals are controlled by a balance between IL-15 and IL-2.

  • * These authors contributed equally to the work.

  • To whom correspondence should be addressed. E-mail: marrackp{at}

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