Role for Rapid Dendritic Protein Synthesis in Hippocampal mGluR-Dependent Long-Term Depression

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Science  19 May 2000:
Vol. 288, Issue 5469, pp. 1254-1256
DOI: 10.1126/science.288.5469.1254

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A hippocampal pyramidal neuron receives more than 104excitatory glutamatergic synapses. Many of these synapses contain the molecular machinery for messenger RNA translation, suggesting that the protein complement (and thus function) of each synapse can be regulated on the basis of activity. Here, local postsynaptic protein synthesis, triggered by synaptic activation of metabotropic glutamate receptors, was found to modify synaptic transmission within minutes.

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