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Atomic Structure of PDE4: Insights into Phosphodiesterase Mechanism and Specificity

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Science  09 Jun 2000:
Vol. 288, Issue 5472, pp. 1822-1825
DOI: 10.1126/science.288.5472.1822

Article Information

vol. 288 no. 5472 1822-1825

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 7, 2000
  • Accepted for publication April 21, 2000
  • .

Author Information

  1. Robert X. Xu1,
  2. Anne M. Hassell1,
  3. Dana Vanderwall1,
  4. Millard H. Lambert1,
  5. William D. Holmes2,
  6. Michael A. Luther2,
  7. Warren J. Rocque2,
  8. Michael V. Milburn1,
  9. Yingdong Zhao3,*,
  10. Hengming Ke3,,
  11. Robert T. Nolte1,
  1. 1 Department of Structural Chemistry,
  2. 2 Department of Molecular Sciences, Glaxo Wellcome Research and Development, Research Triangle Park, NC 27709, USA.
  3. 3 Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  1. To whom correspondence should be addressed.

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