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Abstract
Circadian clocks are time-keeping systems found in most organisms. In zebrafish, expression of the clock genePeriod3 (Per3) oscillates throughout embryogenesis in the central nervous system and the retina.Per3 rhythmic expression was free-running and was reset by light but not by the developmental delays caused by low temperature. The time of fertilization had no effect on Per3 expression.Per3 messenger RNA accumulates rhythmically in oocytes and persists in embryos. Our results establish that the circadian clock functions during early embryogenesis in zebrafish. Inheritance of maternal clock gene products suggests a mechanism of phase inheritance through ovogenesis.
↵* To whom correspondence should be addressed. E-mail: vincent.laudet{at}ens-lyon.fr
