An Anti-Apoptotic Role for the p53 Family Member, p73, During Developmental Neuron Death

See allHide authors and affiliations

Science  14 Jul 2000:
Vol. 289, Issue 5477, pp. 304-306
DOI: 10.1126/science.289.5477.304

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


p53 plays an essential pro-apoptotic role, a function thought to be shared with its family members p73 and p63. Here, we show that p73 is primarily present in developing neurons as a truncated isoform whose levels are dramatically decreased when sympathetic neurons apoptose after nerve growth factor (NGF) withdrawal. Increased expression of truncated p73 rescues these neurons from apoptosis induced by NGF withdrawal or p53 overexpression. In p73–/– mice, all isoforms of p73 are deleted and the apoptosis of developing sympathetic neurons is greatly enhanced. Thus, truncated p73 is an essential anti-apoptotic protein in neurons, serving to counteract the pro-apoptotic function of p53.

  • * To whom correspondence should be addressed. E-mail: mdfm{at}

View Full Text

Stay Connected to Science