Induction and Maintenance of the Neuronal Cholinergic Phenotype in the Central Nervous System by BMP-9

See allHide authors and affiliations

Science  14 Jul 2000:
Vol. 289, Issue 5477, pp. 313-316
DOI: 10.1126/science.289.5477.313

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Bone morphogenetic proteins (BMPs) have multiple functions in the developing nervous system. A member of this family, BMP-9, was found to be highly expressed in the embryonic mouse septum and spinal cord, indicating a possible role in regulating the cholinergic phenotype. In cultured neurons, BMP-9 directly induced the expression of the cholinergic gene locus encoding choline acetyltransferase and the vesicular acetylcholine transporter and up-regulated acetylcholine synthesis. The effect was reversed upon withdrawal of BMP-9. Intracerebroventricular injection of BMP-9 increased acetylcholine levels in vivo. Although certain other BMPs also up-regulated the cholinergic phenotype in vitro, they were less effective than BMP-9. These data indicate that BMP-9 is a differentiating factor for cholinergic central nervous system neurons.

  • * To whom correspondence should be addressed. E-mail: jbluszta{at}

View Full Text

Stay Connected to Science