Function of an Axonal Chemoattractant Modulated by Metalloprotease Activity

See allHide authors and affiliations

Science  25 Aug 2000:
Vol. 289, Issue 5483, pp. 1365-1367
DOI: 10.1126/science.289.5483.1365

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


The axonal chemoattractant netrin-1 guides spinal commissural axons by activating its receptor DCC (Deleted in Colorectal Cancer). We have found that chemical inhibitors of metalloproteases potentiate netrin-mediated axon outgrowth in vitro. We have also found that DCC is a substrate for metalloprotease-dependent ectodomain shedding, and that the inhibitors block proteolytic processing of DCC and cause an increase in DCC protein levels on axons within spinal cord explants. Thus, potentiation of netrin activity by inhibitors may result from stabilization of DCC on the axons, and proteolytic activity may regulate axon migration by controlling the number of functional extracellular axon guidance receptors.

  • * To whom correspondence should be addressed. E-mail: marctl{at}

View Full Text

Stay Connected to Science

Editor's Blog