10 November 2000
Vol 290, Issue 5494

About The Cover

Cover image expansion

COVER The transcription factor Pit-1 binds recognition sites in cell type-specific target genes in distinct configurations. X-ray cocrystal structures of Pit-1 bound to prolactin (left) and growth hormone (right) promoter elements are superimposed on a background of immunostained adult mouse pituitary tissue showing growth hormone (red), prolactin (green), and nuclei (blue). See page 1127. [Images: tissue, UCSD Cancer Center Digital Imaging Shared Resource and San Diego Supercomputer Center using NPACI Scalable Visualization Tools; structures, H. Viadiu]