PerspectiveSignal Transduction

An Arresting Start for MAPK

See allHide authors and affiliations

Science  24 Nov 2000:
Vol. 290, Issue 5496, pp. 1515-1518
DOI: 10.1126/science.290.5496.1515

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Exactly how signaling proteins know where they need to be in the cell is one of the intriguing mysteries of signal transduction biology. In a Perspective, Pouysségur reviews new results that identify b-arrestin 2 as a scaffolding protein that holds together the different components of a MAPK signaling pathway that activates the transcription factor kinase, JNK3.