Reprogramming X Inactivation

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Science  24 Nov 2000:
Vol. 290, Issue 5496, pp. 1518-1519
DOI: 10.1126/science.290.5496.1518

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Inactivation of one of the two X chromosomes occurs in all cells of female adult mice so that genes are expressed from only one X chromosome. In a Perspective, Clerc and Avner describe an elegant series of experiments in mouse embryos cloned from adult and embryonic female cell nuclei ( Eggan et al. ) that reveal how the inactivation state of the X chromosomes is reprogrammed.