Is S Phase Important for Transcriptional Silencing?

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Science  26 Jan 2001:
Vol. 291, Issue 5504, pp. 608-609
DOI: 10.1126/science.291.5504.608

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Because the silencing of chromatin is dependent on passage of cells through S phase, it has always been assumed that DNA replication is a prerequisite for transcriptional silencing. Now, as Smith and Boeke explain in their Perspective, new work in yeast ( Li et al. , Kirchmaier and Rine) demonstrates that DNA replication is not required for establishing silencing of chromatin in yeast, although it may be crucial for maintenance or heritability of the silent state.