Functional Annotation of Mouse Genome Sequences

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Science  16 Feb 2001:
Vol. 291, Issue 5507, pp. 1251-1255
DOI: 10.1126/science.1058244


With the reports of the DNA sequence of the human and mouse genomes, research attention is now on questions of protein function and interactions, developmental and physiological pathways, and systems biology. The International Mouse Mutagenesis Consortium proposes goals and outlines plans for the next 10 years for annotating the mouse genome and compiling data on mouse mutations. In addition to the challenges of identifying new assays to probe biological functions, more efficient and reliable methods are needed for archiving, managing, analyzing, displaying, and disseminating the complex phenotype data sets resulting from mutagenesis programs. Achieving these goals will require the biomedical research community to improve efficiencies, to reduce costs, and to coordinate international expertise and resources.

  • 1 The members of the IMMC are listed in (21).

  • The viewpoints stated here reflect their personal opinions and not those of the government.

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