PerspectiveCELL CYCLE

Centrioles at the Checkpoint

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Science  23 Feb 2001:
Vol. 291, Issue 5508, pp. 1499-1502
DOI: 10.1126/science.291.5508.1499

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Cell biologists have long debated whether the cellular organelle called the centriole can be dispensed with during cell division. In a lively Perspective, Murray discusses new findings ( Piel et al. and Hinchcliffe et al.) suggesting that centrioles play a part in new checkpoints that control cell division and the ability of divided cells to replicate their DNA.