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Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

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Science  01 Jun 2001:
Vol. 292, Issue 5522, pp. 1728-1731
DOI: 10.1126/science.292.5522.1728

Article Information

vol. 292 no. 5522 1728-1731

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 19, 2001
  • Accepted for publication April 30, 2001
  • .

Author Information

  1. Han Cho1,
  2. James Mu2,6,
  3. Jason K. Kim6,7,
  4. Joanne L. Thorvaldsen3,6,
  5. Qingwei Chu2,6,
  6. E. Bryan Crenshaw III4,
  7. Klaus H. Kaestner5,
  8. Marisa S. Bartolomei3,6,
  9. Gerald I. Shulman6,7,
  10. Morris J. Birnbaum2,6,*
  1. 1 Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
  2. 2 Department of Medicine,
  3. 3 Department of Cell and Developmental Biology,
  4. 4 Department of Neuroscience, and
  5. 5 Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
  6. 6 Howard Hughes Medical Institute and the
  7. 7 Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

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