Research Article

Spike Transmission and Synchrony Detection in Networks of GABAergic Interneurons

See allHide authors and affiliations

Science  22 Jun 2001:
Vol. 292, Issue 5525, pp. 2295-2299
DOI: 10.1126/science.1061395

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


The temporal pattern and relative timing of action potentials among neocortical neurons may carry important information. However, how cortical circuits detect or generate coherent activity remains unclear. Using paired recordings in rat neocortical slices, we found that the firing of fast-spiking cells can reflect the spiking pattern of single-axon pyramidal inputs. Moreover, this property allowed groups of fast-spiking cells interconnected by electrical and γ-aminobutyric acid (GABA)–releasing (GABAergic) synapses to detect the relative timing of their excitatory inputs. These results indicate that networks of fast-spiking cells may play a role in the detection and promotion of synchronous activity within the neocortex.

  • * To whom correspondence should be addressed. E-mail: galarreta{at}

View Full Text

Stay Connected to Science