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T Cell Death and Memory

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Science  13 Jul 2001:
Vol. 293, Issue 5528, pp. 245-248
DOI: 10.1126/science.1062416

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In typical immune responses, contact with antigen causes naı̈ve T cells to proliferate and differentiate into effector cells. After the pathogen is destroyed, most effector T cells are eliminated—thereby preserving the primary T cell repertoire—but some cells survive and form long-lived memory cells. During each stage of this process, the life or death fate of T cells is strictly regulated.

  • * To whom correspondence should be addressed: jsprent{at}scripps.edu

  • Present address: The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, UK.

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