News FocusGenetics

Can SNPs Deliver on Susceptibility Genes?

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Science  27 Jul 2001:
Vol. 293, Issue 5530, pp. 593-595
DOI: 10.1126/science.293.5530.593

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Minor differences in people's DNA ought to predict their risk of complex diseases that are not caused by a defect in a single gene but rather arise from the interaction of multiple genes and environmental factors. Is research on these so-called single-nucleotide polymorphisms (SNPs), locations along the chromosomes where a single base varies among different people, living up to its promise? Although the premise of SNP mapping is simple, the reality is that the search for susceptibility genes is still painstakingly slow.