Defining Disease in the Genomics Era

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Science  03 Aug 2001:
Vol. 293, Issue 5531, pp. 807-808
DOI: 10.1126/science.1062938

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  • Defining Disease Is Not Straightforward
    • , Visiting Professor
    • Other Contributors:

    In their Essay, Temple, McLeod, Gallinger, and Wright explore the concept of disease in light of recent and anticipated advances in genomics. However, they do not appear to have taken into account the substantial literature addressing this topic, over several decades within numerous disciplines, and thus their Essay clouds further the already turbid waters of discussion.

    Their definition that a disease is a...

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    Competing Interests: None declared.
  • The Conpect of Disease Gone by 2020?
    • , MD-PhD student
    • Other Contributors:

    According to Francis Collins and Victor McKusick, "By 2020, it is likely that every tumor will have a precise molecular fingerprint determined, cataloging the genes that have gone awry, and therapy will be individually targeted to that fingerprint" (1). At least in the case of cancer, then, the concept of disease will begin to disappear.

    The basic assumptions in giving someone a diagnosis of, for example, squam...

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    Competing Interests: None declared.

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