Enforcement of Temporal Fidelity in Pyramidal Cells by Somatic Feed-Forward Inhibition

See allHide authors and affiliations

Science  10 Aug 2001:
Vol. 293, Issue 5532, pp. 1159-1163
DOI: 10.1126/science.1060342

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


The temporal resolution of neuronal integration depends on the time window within which excitatory inputs summate to reach the threshold for spike generation. Here, we show that in rat hippocampal pyramidal cells this window is very narrow (less than 2 milliseconds). This narrowness results from the short delay with which disynaptic feed-forward inhibition follows monosynaptic excitation. Simultaneous somatic and dendritic recordings indicate that feed-forward inhibition is much stronger in the soma than in the dendrites, resulting in a broader integration window in the latter compartment. Thus, the subcellular partitioning of feed-forward inhibition enforces precise coincidence detection in the soma, while allowing dendrites to sum incoming activity over broader time windows.

  • * To whom correspondence should be addressed. E-mail: massimo{at}

View Full Text

Stay Connected to Science