Immunocyte Ca2+ Influx System Mediated by LTRPC2

See allHide authors and affiliations

Science  17 Aug 2001:
Vol. 293, Issue 5533, pp. 1327-1330
DOI: 10.1126/science.1062473

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


We characterized an activation mechanism of the human LTRPC2 protein, a member of the transient receptor potential family of ion channels, and demonstrated that LTRPC2 mediates Ca2+ influx into immunocytes. Intracellular pyrimidine nucleotides, adenosine 5′-diphosphoribose (ADPR), and nicotinamide adenine dinucleotide (NAD), directly activated LTRPC2, which functioned as a Ca2+-permeable nonselective cation channel and enabled Ca2+ influx into cells. This activation was suppressed by intracellular adenosine triphosphate. These results reveal that ADPR and NAD act as intracellular messengers and may have an important role in Ca2+ influx by activating LTRPC2 in immunocytes.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: sano.yorikata{at}

View Full Text

Stay Connected to Science