The Origin and Control of Pandemic Influenza

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Science  07 Sep 2001:
Vol. 293, Issue 5536, pp. 1776-1777
DOI: 10.1126/science.1063817

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What would happen if a flu pandemic as devastating as the 1918 Spanish flu arrived tomorrow. As Laver explains in a Perspective, preparation of the appropriate subunit vaccine (which depends on accurate identification of the flu virus strain) would take too long. He suggests that stockpiling antiviral drugs such as Relenza and Tamiflu, which block the action of the flu neuraminidase enzyme preventing spread of the virus throughout the host's body, would be a good place to start.

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