Segregation of Human Neural Stem Cells in the Developing Primate Forebrain

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Science  07 Sep 2001:
Vol. 293, Issue 5536, pp. 1820-1824
DOI: 10.1126/science.1060580

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Many central nervous system regions at all stages of life contain neural stem cells (NSCs). We explored how these disparate NSC pools might emerge. A traceable clone of human NSCs was implanted intraventricularly to allow its integration into cerebral germinal zones of Old World monkey fetuses. The NSCs distributed into two subpopulations: One contributed to corticogenesis by migrating along radial glia to temporally appropriate layers of the cortical plate and differentiating into lamina-appropriate neurons or glia; the other remained undifferentiated and contributed to a secondary germinal zone (the subventricular zone) with occasional members interspersed throughout brain parenchyma. An early neurogenetic program allocates the progeny of NSCs either immediately for organogenesis or to undifferentiated pools for later use in the “postdevelopmental” brain.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed at present address: Beth Israel Deaconess Medical Center, Department of Neurology, 855 Harvard Institute of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. E-mail: esnyder1{at} or vouredni{at}

  • Co-senior authors.

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