Smallpox Vaccinations: How Much Protection Remains?

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Science  02 Nov 2001:
Vol. 294, Issue 5544, pp. 985
DOI: 10.1126/science.294.5544.985

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Immunity from smallpox vaccination is widely assumed to decline rapidly, and those vaccinated 30 or more years ago are now unprotected. But a handful of researchers who have examined the scientific literature, including century-old studies as well as state-of-the-art explorations of immunologic memory, believe protection may be far more durable.