A Phosphatase Associated with Metastasis of Colorectal Cancer

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Science  09 Nov 2001:
Vol. 294, Issue 5545, pp. 1343-1346
DOI: 10.1126/science.1065817

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To gain insights into the molecular basis for metastasis, we compared the global gene expression profile of metastatic colorectal cancer with that of primary cancers, benign colorectal tumors, and normal colorectal epithelium. Among the genes identified, the PRL-3 protein tyrosine phosphatase gene was of particular interest. It was expressed at high levels in each of 18 cancer metastases studied but at lower levels in nonmetastatic tumors and normal colorectal epithelium. In 3 of 12 metastases examined, multiple copies of the PRL-3 gene were found within a small amplicon located at chromosome 8q24.3. These data suggest that thePRL-3 gene is important for colorectal cancer metastasis and provide a new therapeutic target for these intractable lesions.

  • * On leave from the University of Torino, Institute for Cancer Research, 10060 Candiolo, Torino, Italy.

  • To whom correspondence should be addressed. E-mail: kinzlke{at} (K.W.K.); vogelbe{at} (B.V.)

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