PerspectiveMolecular Biology

Methylation Talk Between Histones and DNA

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Science  07 Dec 2001:
Vol. 294, Issue 5549, pp. 2113-2115
DOI: 10.1126/science.1066726

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The addition of methyl groups to DNA or histones is a way to directly or indirectly silence gene expression. Although the two events are conceivably connected, they have always been studied separately. In his Perspective, Bird explores the exciting notion (supported by data published elsewhere) that the two events are irrevocably linked, that is, DNA methylation depends on histone methylation.