Genomic Views of Genome Duplication

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Science  14 Dec 2001:
Vol. 294, Issue 5550, pp. 2301-2304
DOI: 10.1126/science.1067929

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DNA replication is initiated at numerous origins of replication (oris) within the chromosomes. In a pair of ambitious studies, two groups have used different techniques to pinpoint the locations of all of the oris throughout the yeast genome at different times during S phase ( Raghuraman et al., Wyrick et al.). Stillman, in his Perspective, compares and contrasts the different methods and their findings, and speculates on the value of combining these techniques to look at oris in the human genome.