Coenzymes and Radicals

See allHide authors and affiliations

Science  21 Dec 2001:
Vol. 294, Issue 5551, pp. 2489-2490
DOI: 10.1126/science.1067916

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Organic radicals play an important role in many enzymatic reactions, but as Frey explains in his Perspective, information about their structure is hard to come by. He highlights the report by Chabrière et al., who have crystallized the enzyme pyruvate:ferredoxin oxidoreductase with the intermediate radical form of hydroxyethylidene-thiamine pyrophosphate bound to its active site. The structure of the radical provides important clues to its electronic structure.