Switching Partners in a Regulatory Tango

See allHide authors and affiliations

Science  21 Dec 2001:
Vol. 294, Issue 5551, pp. 2497-2498
DOI: 10.1126/science.1067622

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


The coactivator CBP/p300 cooperates with the enzyme CARM1 to boost the activity of the nuclear hormone receptor transcription factors. But what is the relationship between CBP/p300 and CARM1? As Nishioka and Reinberg explain in their Perspective, new work reveals that CARM1 regulates the availability of CBP/p300 by methylating the KIX domain of this coactivator.