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Extension of Life-Span in Caenorhabditis elegans by a Diet Lacking Coenzyme Q

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Science  04 Jan 2002:
Vol. 295, Issue 5552, pp. 120-123
DOI: 10.1126/science.1064653

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Abstract

The isoprenylated benzoquinone coenzyme Q is a redox-active lipid essential for electron transport in aerobic respiration. Here, we show that withdrawal of coenzyme Q (Q) from the diet of wild-type nematodes extends adult life-span by ∼60%. The longevity of clk-1,daf-2, daf-12, and daf-16 mutants is also extended by a Q-less diet. These results establish the importance of Q in life-span determination. The findings suggest that Q and thedaf-2 pathway intersect at the mitochondria and imply that a concerted production coupled with enhanced scavenging of reactive oxygen species contributes to the substantial life-span extension.

  • * To whom correspondence should be addressed. E-mail: larsen{at}chem.ucla.edu

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