Oxygen Sensing Gets a Second Wind

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Science  01 Feb 2002:
Vol. 295, Issue 5556, pp. 807-808
DOI: 10.1126/science.1069825

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The recent discovery of molecules that mediate the hypoxia response pathway demonstrates that mammalian cells are supremely well adapted to dealing with conditions of low oxygen. In their Perspective, Bruick and McKnight detail new findings ( Lando et al.) that describe an additional way in which the transcription factor HIF, a central player in the hypoxia response pathway, can be regulated.