A Tomato Cysteine Protease Required for Cf-2-Dependent Disease Resistance and Suppression of Autonecrosis

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Science  26 Apr 2002:
Vol. 296, Issue 5568, pp. 744-747
DOI: 10.1126/science.1069288

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Little is known of how plant disease resistance (R) proteins recognize pathogens and activate plant defenses. Rcr3 is specifically required for the function of Cf-2, aLycopersicon pimpinellifolium gene bred into cultivated tomato (Lycopersicon esculentum) for resistance toCladosporium fulvum. Rcr3 encodes a secreted papain-like cysteine endoprotease. Genetic analysis shows Rcr3 is allelic to the L. pimpinellifolium Ne gene, which suppresses the Cf-2–dependent autonecrosis conditioned by its L. esculentum allele, ne (necrosis).Rcr3 alleles from these two species encode proteins that differ by only seven amino acids. Possible roles of Rcr3 in Cf-2–dependent defense and autonecrosis are discussed.

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