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Abstract
Little is known of how plant disease resistance (R) proteins recognize pathogens and activate plant defenses. Rcr3 is specifically required for the function of Cf-2, aLycopersicon pimpinellifolium gene bred into cultivated tomato (Lycopersicon esculentum) for resistance toCladosporium fulvum. Rcr3 encodes a secreted papain-like cysteine endoprotease. Genetic analysis shows Rcr3 is allelic to the L. pimpinellifolium Ne gene, which suppresses the Cf-2–dependent autonecrosis conditioned by its L. esculentum allele, ne (necrosis).Rcr3 alleles from these two species encode proteins that differ by only seven amino acids. Possible roles of Rcr3 in Cf-2–dependent defense and autonecrosis are discussed.
↵* To whom correspondence should be addressed. E-mail jonathan.jones{at}bbsrc.ac.uk
