Chromatin Control--a Place for E2F and Myc to Meet

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Science  10 May 2002:
Vol. 296, Issue 5570, pp. 1034-1035
DOI: 10.1126/science.1072446

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The transcription factor E2F switches on target genes during the early Gphase of the cell cycle. In his Perspective, La Thangue discusses new findings ( Ogawa et al.) that reveal the importance of an E2F family member, E2F-6, for silencing genes in quiescent cells in Gof the cell cycle.