DATABASE: In the Genes

See allHide authors and affiliations

Science  31 May 2002:
Vol. 296, Issue 5573, pp. 1575
DOI: 10.1126/science.296.5573.1575b

For Japanese people, the odds of having the metabolic disorder phenylketonuria are a piffling 1 in 119,000, but the chances are 26 times higher for someone from Ireland. Knowing how the frequency of inherited diseases varies from place to place is essential for doctors and health care planners—and the information can even reveal patterns of human evolution and past migrations. This new database from the University of Wales gathers figures on the prevalence of more than 280 inherited disorders, including cystic fibrosis, Tay-Sachs disease, and Fanconi anemia. The entries draw from more than 1000 studies, providing frequency data and links to the original abstracts in PubMed.

Stay Connected to Science

Navigate This Article