Special Viewpoints

TNF-R1 Signaling: A Beautiful Pathway

See allHide authors and affiliations

Science  31 May 2002:
Vol. 296, Issue 5573, pp. 1634-1635
DOI: 10.1126/science.1071924

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Tumor necrosis factor (TNF) is a major mediator of apoptosis as well as inflammation and immunity, and it has been implicated in the pathogenesis of a wide spectrum of human diseases, including sepsis, diabetes, cancer, osteoporosis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases. The interaction of TNF with TNF receptor–1 (TNF-R1) activates several signal transduction pathways. A common feature of each pathway is the TNF-induced formation of a multiprotein signaling complex at the cell membrane. Over the past decade, many of the components and mechanisms of these signaling pathways have been elucidated. We provide an overview of current knowledge of TNF signaling and introduce an STKE Connections Map that depicts a canonical view of this process.

  • * To whom correspondence should be addressed. E-mail: goeddel{at}tularik.com

View Full Text

Stay Connected to Science