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Control of T Cell Function by Positive and Negative Regulators

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Science  31 May 2002:
Vol. 296, Issue 5573, pp. 1639-1640
DOI: 10.1126/science.1071551

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T cells are an essential element of the body's immune system. Engagement of the T cell receptor is responsible for initiating the signaling events that can activate, inactivate, or eliminate T cells, depending on the magnitude and duration of the signal. Control of T cell signaling occurs through both positive and negative regulation, as well as through the actions of molecular scaffolds that contribute to the formation of signaling complexes. The T Cell Signal Transduction Pathway at the STKE Connections Maps highlights the molecular components that are responsible for T cell activation. Understanding the mechanisms that regulate T cell responsiveness will aid in the development of therapeutic agents to treat infection, cancer, and autoimmune disease and immune deficiency.

  • * To whom correspondence should be addressed. E-mail: koretzky{at}mail.med.upenn.edu

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