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A Natural Product That Lowers Cholesterol As an Antagonist Ligand for FXR

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Science  31 May 2002:
Vol. 296, Issue 5573, pp. 1703-1706
DOI: 10.1126/science.1072891

Article Information

vol. 296 no. 5573 1703-1706

PubMed: 
Print ISSN: 
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History: 
  • Received for publication February 20, 2002
  • Accepted for publication April 23, 2002
  • .

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Author Information

  1. Nancy L. Urizar1,
  2. Amy B. Liverman2,
  3. D'Nette T. Dodds1,
  4. Frank Valentin Silva1,
  5. Peter Ordentlich3,
  6. Yingzhuo Yan3,
  7. Frank J. Gonzalez4,
  8. Richard A. Heyman3,
  9. David J. Mangelsdorf2,
  10. David D. Moore1,*
  1. 1 Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
  2. 2 Howard Hughes Medical Institute, University of Texas - Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
  3. 3 X-Ceptor Therapeutics, Inc., 4757 Nexus Center Drive, San Diego, CA 92121, USA.
  4. 4 Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Building 37, Room 3E24, Bethesda, MD 20892, USA.

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