Targeting Lymphatic Metastasis

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Science  07 Jun 2002:
Vol. 296, Issue 5574, pp. 1811-1812
DOI: 10.1126/science.10731318

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Oncologists have long debated the part played by the lymphatic system of cancer patients in tumor metastasis. In a Perspective, Gershenwald and Fidler discuss new findings ( Padera et al.) showing that the lymphatic vessels surrounding tumors contribute to lymphatic metastasis. The authors propose that one therapeutic approach to preventing lymphatic metastasis is to block VEGF-C, a lymphangiogenic factor.