T Cell Activation in Six Dimensions

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Science  07 Jun 2002:
Vol. 296, Issue 5574, pp. 1815-1817
DOI: 10.1126/science.296.5574.1815

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What are T cells doing deep within the recesses of the lymph nodes they inhabit? In his Perspective, von Andrian discusses the findings of several studies that use two-photon and confocal microscopy to illuminate (literally) the private lives of T cells.