Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic Protease

See allHide authors and affiliations

Science  21 Jun 2002:
Vol. 296, Issue 5576, pp. 2215-2218
DOI: 10.1126/science.1070925

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Signal peptide peptidase (SPP) catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. In humans, SPP activity is required to generate signal sequence–derived human lymphocyte antigen–E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. We have identified human SPP as a polytopic membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. SPP and potential eukaryotic homologs may represent another family of aspartic proteases that promote intramembrane proteolysis to release biologically important peptides.

  • * To whom correspondence should be addressed. E-mail: bruno.martoglio{at}

View Full Text

Stay Connected to Science